Friends, after the Monica's jellyfish sting
Joey: That’s right I stepped up! She’s my friend and she needed help!
And if I had too, I’d pee on anyone of you!
(gets me every time)
From Blackadder III:
Amy: He says my nosy is tiny ?
Edmund: And wee, madam.
A: Well he must be an awful clever clogs, because you see, my nosy is
tiny, and so wee, that I sometimes think the pixies gave it to me!
(While Richardson's delivery is fantastic, it's Atkinson's expression. The utter disbelief on his face...)
Frasier
(When Frasier and Niles compete which will get a better present to their dad, and Frasier gets the giant screen TV)
Frasier: Just think how a screen this size will enhance the majesty of the Metropolitan Opera, or the thrilling artists of the Bolshoi
Niles (WITH A BIT OF VENOM): You're quite a Bolshoi artist yourself (!)
classic quote from Moonlighting:
Maddie: David, I don't think...
David: That's OK, Maddie, you look good.