I agree with what enigmatic has said and that it is an improvement on the first draft. However my favourite line is the 'centerpieces' one, from experience.
It still has the feel of a studio based first scene with the back and forth between the two and that this idea can be so much more than that and the comedy should come from awkward or real life characters who are relatable.
It can be different to some of the dross, unfunny, safe sitcoms on the T.V recently and can have the perfect mix of comedy and drama. But if you do send it to producers they are likely to be scared to do anything with it due to the word 'cancer'.
I have to say I'm dissapointed it's been put on the 'back burner' and after watching the YouTube video I think you're very good at this genre of comedy. But I hope you post more ideas on here.