Interesting stuff in this BBC documentary on the changing role of disability in comedy with excerpts from well known recent examples such as The Office, Little Britain, Phoenix Nights and Extras.
Trying to recall the earliest comedy I remember with a disability theme and thinking about it was the most unlikely of comedy characters; Alf Garnett.
Dandy Nichols was confined to a wheelchair in the later episodes of In Sickness And In Health and contained some well written scenarios with Alf coping with life with a disabled wife as well using her to queue jump to the max.