Afinkawan
Wednesday 8th July 2009 4:29pm [Edited]
Huddersfield
2,302 posts
Quote: sootyj @ July 8 2009, 12:01 PM BST
Most of the companies that make these drugs seem to be fairly straight up about how little they do.
Mostly what we're talking about here is cancer drugs. yes, companies are up front about what they do or don't do or how effective they are. Most of the stories that make the newspapers are where someone is refused £30k worth of drugs that has a slight chance of increasing their life span by about a year at most.
Usually, in other patients, the same drug might well extend life by many years or make a massive improvement in quality of life.
The one I'm working on at the moment seems to be great at second line breast cancer treatment (i.e. when something else has stopped working/failed to work) but is too toxic to use as first line treatment but is also effective for bladder and pancreatic cancers. Chances are NICE will only pass it for bladder as most people with pancreatic cancer don't find out until it's far too late at which point the drug is not much use routinely. But they might also allow its non-routine use if the pancreatic cancer is diagnosed early enough - where it might be an effective treatment instead of a mild life extender.
Quote: Tim Walker @ July 8 2009, 1:28 PM BST
they really do have to invest billions in research of new chemotherapies. This money has to be recouped somehow. (And remember, drug patents run out relatively quickly, which is why you have cheap aspirin, paracetamol, ibuprofen, plus cheap generic versions of very successful and safe specialist medicines which originally cost millions to develop.)
You're not kidding. The one I mentioned above - my job is basically to oversee it moving from bench-scale R&D product to routine manufacturing, ready to submit to the regulatory authorities for licensing. The first proper scale test of this was back in 2001 and it had been knocking about as a purely R&D thing for several years before that. Each batch of the active ingredient we use costs about £2million to make. That's just the active ingredient, that's not the final cost of making it, with all the other ingredients, the time, the equipment, the services to that equipment, the inspection of the product, the vials, stoppers and caps to fill it, the packaging for it to go into etc. etc. etc.
We'll probably get a ten-year patent out of it.