U Talkin U2 To Me is outstanding regardless on where you stand on U2.
The current love of my podcast life is Hollywood Handbook. I've learned so much about 'the biz' from Hayes & Sean.
Best comedy podcasts? Page 8
I'm doing loads of research on this at the moment. Plumbing the Death Star is right up there for me at the moment - one episode, entitled the Ethics of Azkaban, is properly ace.
Three chaps arguing the issues of keeping wizards in prison - I'll take that!
The Adam Buxton podcast on iTunes/Sound cloud is very interesting and funny.